[7]–[13] The expression of DACH1 was regulated by promoter region hypermethylation in endometrial, colorectal and hepatocellular cancer. [11]–[13]DACH1 suppressed human hepatocellular carcinoma by activating TGF-β signaling. [13] While the epigenetic changes and the function of DACH1 in human ESCC remain unclear. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.