IL6 and influenza: In line with this result, IPA identified the following canonical pathways as significantly downregulated: “Acute phase response signaling” (P = 5.94e-4), “Role of hypercytokinemia/hyperchemokinemia in pathogenesis of Influenza (P = 1.19e-3), “IL-6 signaling” (P = 1.18e-3), “Agranulocyte adhesion and diapedesis” (P = 8.82e-6), “Granulocyte adhesion and diapedesis” (P = 6.55e-9) and “Role of cytokines in mediating communication between immune cells” (P = 0.017) (Figure S1E).