Notably, all differentially expressed genes encoding cytokines and chemokines that have been associated with P. falciparum-induced fever and inflammation [2]–[4], [32], including the canonical pyrogenic cytokines IL1B and TNF as well as the pro-inflammatory chemokines IL8, CCL3 (MIP-1α) and CXCL2 (MIP-2α), were suppressed after the resolution of malaria to lower levels than observed at baseline (Figure 1A). Here, IL1B is linked to malaria.