IL10 and malaria: The exposure-dependent inducibility of IL-10 production by Th1 cells may also explain our previous observation at the same study site that children with asymptomatic P. falciparum infection at the end of the dry season are at lower risk of febrile malaria during the ensuing malaria season [31], whereas uninfected children at the end of the dry season are at increased risk—corresponding temporally with their return to a homeostatic baseline in which P. falciparum exposure induces a pro-inflammatory phenotype.