KIAA0586 and polydactyly: The talpid3 chicken provides a classic model for studying human ciliopathies and Hh signaling, exhibiting many ciliopathy phenotypes, including polydactyly,27 polycystic kidneys28 and a loss of endochondral bone ossification29 and has been useful in elucidating the role of Hh signaling in limb and neural tube development.27