To date, more than 150 mutations in RyR2 have been associated with different forms of cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (CPVT), catecholaminergic idiopathic ventricular fibrillation, and atrial fibrillation [2]–[5]. This evidence concerns the gene RYR2 and chronic obstructive pulmonary disease.