ACOT1 and fatty liver disease: Several other frequently deleted regions were also observed including one at 16q12.2 harbouring the carboxylesterase 1 (CES1) gene and one at 14q24.3 spanning the acyl-CoA thioesterase 1 (ACOT1) gene; importantly, both genes are known to promote hepatic steatosis via the action of regulation of hepatic lipid metabolism [29]–[30].