AKT1 and renal carcinoma: In this study, we investigated whether natural compounds enhance NVP-BEZ235-induced PI3K-Akt-mTOR signaling inhibition and cell death in human renal carcinoma Caki cells, and the molecular mechanisms underlying co-treatment with curcumin and NVP-BEZ235 were analyzed in human renal carcinoma Caki cells.