FGFR1 and hepatocellular carcinoma: Huang et al. confirmed that livers of transgenic FGFR1 mice exhibited accelerated regeneration after PH, meanwhile the persistent activity of ectopic FGFR1 in hepatocytes was a strong promoter of hepatocellular carcinoma by driving cell proliferation at early stages and promoting neo-angiogenesis at late stages of progression [39].