Tomoya Yamaguchi, et al [20] also found that TTF-1 can induce ROR1 (tyrosine kinase orphan receptor 1) expression, which in turn sustains a favorable balance between the prosurvival PI3K-AKT and proapoptotic p38 signaling pathways; which is in part through ROR1 kinase-dependent c-Src activation as well as kinase activity-independent sustainment of the EGFR-ERBB3 association, ERBB3 phosphorylation and consequential PI3K activation.it also indicates TTF-1 expressions have correlation with EGFR, which can promote the growth of tumor cells. The gene discussed is ROR1; the disease is neoplasm.