DNMT3L and cancer: In our previous study, we had identified a CpG island spanning the promoter (DNMT3L-002, Ensembl Transcript ID ENST00000431166) and Exon 1 (DNMT3L-001, Ensembl Transcript ID ENST00000270172) of the human DNMT3L gene that showed loss of DNA methylation in different cancers [16], [17].