MLH1 and colorectal carcinoma: In agreement with this rationale, the main aim of the present study was to assess the implication of the c.1852_1853delinsGC (p.K618A) variant in the MLH1 gene as a low-penetrance risk variant for CRC by performing a case-control study within a large cohort from the COGENT consortium-COST Action BM1206, an international effort to facilitate the study of inherited genetic predisposition to CRC [21], [22].