It is interesting that SC adipose tissue C3 mRNA expression decreases with increasing adiposity given that plasma C3 levels are usually positively associated with obesity, metabolic dysfunction, insulin resistance, cardiovascular disease and type 2 diabetes [39], [9], [7], [2] while partial lipodystrophy is associated with hypocomplementemia [40]. Here, C3 is linked to obesity due to melanocortin 4 receptor deficiency.