Our finding can be explained by a study [34] demonstrating that the proliferation of peritumoral CD8+ CTLs was suppressed by FOXP3+ Tregs which infiltrated and were then activated only in breast tumor stroma and thus associated with worse survival of patients; within tumor cells nests, in contrast, lower density FOXP3+ Tregs were not activated and therefore had no ability to suppress intratumoral CD8+ CTLs. This evidence concerns the gene CD8A and neoplasm.