For example, recent work suggests that single nucleotide polymorphisms (SNPs) within BIM influence its splicing in cis. Specifically, a C>T SNP (rs724710) in BIM exon 4 has been shown to affect the inclusion of BIM exon 3, and may contribute to drug resistance in acute lymphoblastic leukemia [18]. Here, BCL2L11 is linked to acute lymphoblastic leukemia.