The functions of JNK and p38 MAPK in cancer cells are complex; P38 MAPK and JNK1/2 play a crucial role in cellular stress responses, signaling for cell cycle arrest [42] and apoptosis [17, 43], yet, in some cases p38 MAPK and JNK enzymes are associated with cell survival, aggressive cancer phenotypes including invasiveness. The gene discussed is MAPK8; the disease is cancer.