Unexpectedly, we observed that the ccRCC patients carrying the mutation were younger than those having a wild type TERT promoter, although the difference was not statistically significant [mutation+ vs -: 50 ±12 (mean ± 12) vs 55 ± 11, P = 0.142] (Table 3). This evidence concerns the gene TERT and nonpapillary renal cell carcinoma.