As demonstrated in preclinical models, this variant may confer resistance to c-MET inhibitors.[18] Clinical data suggested that this variant might decrease the risk of gastric cancer, probably through reduced affinity of HGF to the c-MET receptor.[26] Although similar prognostic implication was not confirmed in lung cancer, decreased cell death upon treatment with a c-MET inhibitor was showed in the presence of N375S variant.[27] In the light of our findings, the correlation of this variant and response to c-MET targeted agents is worth of further investigation. The gene discussed is HGF; the disease is lung cancer.