MET and gastric cancer: Paracrine HGF-induced activation of c-MET plays in important role in the pathogenesis of gastric cancers.[10] Moreover, MET gene amplification is one of the well-recognized mechanisms of c-MET overexpression and constitutive activation of MET/HGF pathway [11], and has been reported in 2% to 10% of GE adenocarcinomas.[12, 13] The results of the same studies showed that MET positivity is an independent factor for poor survival regardless of disease stage.