HGF and neoplasm: Many c-MET inhibitors are currently in development and some of them showed activity for GE tumors.[16] In a recent case series, two out of four patients with MET-amplified GEJ cancers had some tumor shrinkage with crizotinib, a c-MET inhibitor.[12] Rilotumumab is a humanized monoclonal antibody against HGF, and, thus, can interfere with the interaction of HGF and c-MET preventing receptor activation.