Reduction in cell proliferation and/or colony formation was observed in several melanoma cell lines and in cells freshly isolated from human biopsies harboring the BRAFV600E mutation (501mel, A375, WM9 and C.09-02) or the NRASQ61K/R mutation (HMVII and C.12-38) or in cells wild-type for BRAF and NRAS (SBCL2, Mel-ST) (Figures 2D-H, S1A-B). Here, NRAS is linked to melanoma.