In tumors of epithelial origin (carcinomas), cancer progression is associated with dramatic changes in cell–cell or E-cadherin-mediated adhesion, as well as aberrant organization of cell polarity and cytoskeleton architecture (Beavon 2000; Conacci-Sorrell et al. 2002; Wodarz and Nathke 2007). This evidence concerns the gene CDH1 and cancer.