As N-Myc oncoprotein up-regulates JMJD1A expression and JMJD1A induces MALAT1 expression, our data suggest that N-Myc oncoprotein induces neuroblastoma cell migration and invasion through up-regulating JMJD1A expression, and that JMJD1A induces neuroblastoma cell migration and invasion through up-regulating MALAT1 expression. The gene discussed is KDM3A; the disease is neuroblastoma.