In summary, this study demonstrates that a novel pathway, involving transcriptional up-regulation of JMJD1A, which demethylates histone H3K9 at MALAT1 gene promoter and activates MALAT1 gene transcription, plays an important role in N-Myc oncoprotein-mediated neuroblastoma cell migration and invasion. Here, MALAT1 is linked to neuroblastoma.