As stable MALAT1 knockout in lung cancer cells up-regulates HTR2B expression [13] and silencing of HTR2B is a marker for ovarian tumor metastasis in ovarian cancer patients [34], we propose that repression of HTR2B expression contributes to MALAT1-mediated tumor cell migration, invasion and metastasis. The gene discussed is HTR2B; the disease is ovarian neoplasm.