RT-PCR studies confirmed that transfection with JMJD1A siRNA-1, JMJD1A siRNA-2, N-Myc siRNA-1 or N-Myc siRNA-2 significantly increased FAM73A and HTR2B mRNA expression in neuroblastoma cells (Fig. 2E). This evidence concerns the gene KDM3A and neuroblastoma.