However, cells derived from stem cells, e.g., progenitor cells,have functional GJs, suggesting that GJIC develops during differentiation [20-22].Recently, in human spheroidal glioma cultures, reduced GJIC and very low levels of Cx43were identified as mediators of self-renewal, invasiveness, and tumorigenicity byinfluencing E-cadherin expression, a marker of epithelial-mesenchymal transition (EMT)[23]. The gene discussed is CDH1; the disease is glioma.