Conversely, anticancer activities of NGAL have been demonstrated by its ability to inhibit the pro-neoplastic factor HIF-1a, the synthesis of HIF-1a-dependent VEGF [16,17], and phosphorylation of FAK kinase [17], as shown in colon [18], ovarian [19] and pancreatic [17] cancers. This evidence concerns the gene HIF1A and cancer.