It was observed that expression of ICAM-1 in DU145/sh-E2F1 tumors was higher than control and DU145/sh-ICAM-1 tumors (Figures 5E and F), indicating that the increase in ICAM-1 expression is correlated to suppression of DU145 xenograft tumor growth by E2F1 knockdown. The gene discussed is E2F1; the disease is neoplasm.