GNRH1 and central precocious puberty: Confirmed CPP or EP: a) onset of breast development (stage B2 or above according to Tanner) before a chronological age of 9 yrs, b) pubertal LH response (>7 IU/liter) to a GnRH stimulation test, c) advancement of bone age over chronological age by at least 1 yr, d) pubertal uterine and ovarian volume at pelvic ultrasonography[24].