Finally, saxagliptin and alogliptin, as representatives of the innovative class of dipeptidyl-peptidase-4 (DPP-4) inhibitors have recently failed to demonstrate significant CV outcome benefits in the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR-TIMI 53) and the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial [7,8], respectively. The gene discussed is DPP4; the disease is diabetes mellitus.