CCNE1 and esophageal adenocarcinoma: In the current study, we (i) used high resolution SNP DNA microarray to study cyclin E amplification in the large scale of esophageal adenocarcinoma and precancerous lesions; (ii) used immunohistochemical method to confirm the high expression of cyclin E in a larger number of esophageal adenocarcinoma and precancerous lesions; and (iii) studied the association of cyclin E amplification and high expression with patients’ overall survival and clinicopathological features.