CCNE1 and esophageal adenocarcinoma: It is surprising to find both amplification and high expression of cyclin E in esophageal adenocarcinoma in our study were not significantly associated with patient overall survival, even with a little better overall survival rate with high expression of cyclin E. The controversial data for the prognosis was reported in the colon [29,30], ovary [31], stomach [11,12] and lung [9].