STUB1 and hypogonadism: For example, missense mutations in STUB1 encoding the protein CHIP (C-terminus of HSC70-interacting protein), which functions as a molecular co-chaperone and ubiquitin E3 ligase and which interacts with several proteins involved in degenerative ataxia disease [3], have recently been suggested as a cause of early-onset recessive ataxia with hypogonadism [4,5].