PLA2G7 and endothelial dysfunction: As is well documented that endothelial dysfunction, in terms of reduced NO production, plays critical roles on atherosclerosis initiation and progression [29], and additionally, as Lp-PLA2 elevation has been recognized as a new target for therapy in patients with CVD [30], we further investigated the effects of colchicine on endothelial function and Lp-PLA2 level.