Taken together, in light of the crucial roles Lp-PLA2 plays on the initiation and progression of vascular inflammation and atherosclerosis in subjects with hyperlipidemia and the potent effect of colchicine on regulating inflammation, we hypothesized that colchicine might be effective in ameliorating vascular inflammation and improving endothelial function by means of declining Lp-PLA2 level, and if corroborated, we believed that in the future adds colchicines into statins therapy may have additional benefits on CVD prevention and therapy. The gene discussed is PLA2G7; the disease is hyperlipidemia.