PLA2G7 and hyperlipidemia: As presented in Table 2, after 6 weeks of high-fat and high-cholesterol diet administration, NO production in the hyperlipidemic model groups were significantly abolished when compared to the sham group, whereas serum levels of Lp-PLA2 were significantly elevated, indicating that hyperlipidemia might not only contribute to enhanced inflammation but also impaired endothelial function.