The relatively low risk of hypoglycaemia observed with canagliflozin when not used in combination with agents associated with hypoglycaemia (eg, insulin and sulphonylurea) is consistent with its mechanism of action, as canagliflozin lowers the RTG to approximately 4.4 to 5.0 mmol/L [8,17], above the usual threshold for hypoglycaemia of 3.9 mmol/L. Here, INS is linked to Hypoglycemia.