In this analysis, the number of patients on background AHAs associated with hypoglycaemia was small; in these patients, an increased incidence of documented hypoglycaemia was observed with canagliflozin in both age subsets, with no increase in severe events, consistent with previous studies of canagliflozin in patients on background insulin or sulphonylurea [11,13,15,23]. The gene discussed is INS; the disease is Hypoglycemia.