NFKB1 and obesity due to melanocortin 4 receptor deficiency: This hypoxia could be a determinant mediator of obesity-induced inflammation in AT by activating multiple signaling pathways such as Hypoxia Inducible Factor-1α (HIF-1α) and Nuclear Factor kappa B (NF-κB) in adipocytes and macrophages, thereby altering the expression of many proinflammatory adipokines [27–29].