The frequency of Lin-HLA-DR-CD33+CD11b+CD15+ granulocytic subset was greater than monocytic Lin-HLA-DR-CD14+ in the peripheral blood of patients with PC (8.86% versus 0.89%, P = 0.004) and in those with CP (8.95% versus 1.35%, P = 0.003). The gene discussed is CD33; the disease is pachyonychia congenita.