These polypeptides have been associated with various physiological processes such as food intake, energy balance, insulin action, glucose metabolism, vascular remodeling, and blood pressure regulation and coagulation [111, 112]; additionally, high levels of acute phase proteins and inflammatory cytokines in obese individuals have demonstrated that they suffer from a chronic state of low grade inflammation, which has been associated with the development of insulin resistance, metabolic syndrome, and T2DM [113, 114]. This evidence concerns the gene INS and type 2 diabetes mellitus.