Hyperglycemia alone is capable of producing alterations in insulin secretion that decrease when it is corrected, that means that any increase in glycaemia in patients with a decrease in β-cell volume can cause important abnormalities in insulin secretion in the rest of the pancreatic tissue; it also contributes to the increase of insulin resistance and the defects in insulin secretion, which are corrected when glucose levels are reduced [24, 25]. This evidence concerns the gene INS and Hyperglycemia.