HLA-G and melanoma: Moreover, the levels of histone acetylation in the HLA-G promoter chromatin have been reported to be significantly enhanced in FON+ (melanoma) and JEG-3 (Human placental choriocarcinoma cell line) cell lines, both expressing HLA-G, while in non-HLA-G expressing cell lines, such as M8 (melanoma) and JAR, histones seem to be hypomethylated [94, 96, 98].