We demonstrated that in comparison to PAD patients without splenomegaly PAD patients with splenomegaly have a decrease in the frequency of switched memory B cells (4.1 ± 5.4% versus 7.9 ± 6.9%; P = 0.01) and an increased frequency of CD21 low B cells (20.1 ± 18 versus 11.4 ± 10; P = 0.02) confirming our previous data [20]. The gene discussed is CR2; the disease is peripheral arterial disease.