Analysis performed on blasts from patients with different leukemia, including Acute Myeloid Leukemia (AML), Acute Lymphoid Leukemia (ALL), and Chronic Myeloid Leukemia (CML), demonstrated that neither mRNA for any HLA-G isoforms nor HLA-G antigen was detected [20, 21]. This evidence concerns the gene HLA-G and acute lymphoblastic leukemia.