Analysis of the profiles of cytokines in the culture supernatants showed that the tumor-activated γδ T cells secreted substantially more Th1-prone cytokines such as IFN-γ, IL-1, IL-6, and IL-12, but not IL-4 and IL-10, than peripheral-derived γδ T cells did (Figure 1(d); n = 5). This evidence concerns the gene IL4 and neoplasm.