Three biological pathways involved in SLE have been forwarded by Harley et al. [1]: (i) innate immune response including toll-like receptor (TLR)/interferon (IFN) signalling pathways; (ii) adaptive immune response including B, T, and antigen-presenting cells immune signal transduction; and (iii) immune complex clearance mechanism. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.