In addition, the combination of interleukin-4 (IL-4)/GM-CSF/ tumor lysates (TL)/TNF-α induced the greatest differentiation and maturation for DCs in patients with bone and soft tissue tumors in contrast with a combination of IL-4/GM-CSF/TL and a combination of IL-4/GM-CSF/OK-432 [13]. This evidence concerns the gene IL4 and soft tissue neoplasm.