Basing on our finding that Gαs was downregulated in advanced PCa and the previous studies concerning the function of EGFR in PCa, we hypothesise that downexpression of Gαs inhibit the degradation of EGFR, then androgen receptors which are activated by EGFR were prolonged and cell proliferation increased, eventually causing tumor progression and hormone-resistant in prostate cancer. Here, AR is linked to Familial prostate cancer.