Panniculitis was the only manifestation significantly associated with the presence of anti-MDA5 (5 out of 14 anti-MDA5-positive versus 13 out of 103 anti-MDA5-negative; P < 0.05; OR: 3.85, 95% CI 1.11–13.27); nevertheless, a multivariate analysis was not possible to be performed due to methodological reasons. Here, IFIH1 is linked to panniculitis.