APOE and atherosclerosis: Reconstitution of irradiated Ldlr−/− mice with Ccr1−/− bone marrow increased atherosclerotic surface in both the thoracic aorta and the aortic root, indicating that CCR1 opposes atherogenesis [80]. Ccr1−/−ApoE−/− mice have accelerated atherosclerosis relative to ApoE−/− controls.