CCR7 deficiency in ApoE−/− mice exacerbated atherosclerosis, which correlated with a selective increase in circulating T cells and their accumulation in atherosclerotic plaques. Ccr7−/−ApoE−/− mice had increased Th1 and Th17 responses but reduced Th2 and Treg responses [84]. This evidence concerns the gene CCR7 and atherosclerosis.