The gene that encodes CHMP4B protein is found mutated in autosomal dominant cataract [16], a disease with unknown molecular mechanism, even though it is known that it is linked with unsuccessful degradation of cellular organelles and chromosomal DNA during lens cell differentiation from epithelial to fiber cells [15, 21]. The gene discussed is CHMP4B; the disease is Autosomal dominant optic atrophy and cataract.