The aim of the present study was to test whether genetic variants in FKBP5, GR (NR3C1), and CRHR1, previously described to increase the risk for depression, are associated with longitudinal measures of depressive symptoms in a cohort of pregnant women assessed in the third trimester of pregnancy, 2-3 days and 6 months after delivery. The gene discussed is CRHR1; the disease is major depressive disorder.