PDPN and lymphedema: Recently, a subtype with low expression of podoplanin was identified—precollector lymphatic endothelium.23 In knockout mice models (podoplanin −/− or podoplanin +/−), large ectatic podoplanin-negative vessels, impaired lymphatic network patterning, and lymphedema were observed.24 These findings resemble what we have found in the 2 elephantiasis nostras patients.