For example, many studies have shown that aggressive control of blood glucose with insulin reagents or stimulators of insulin secretion such as sulfonylureas is associated with increased mortalities due to various cardiovascular disorders or cancer (Eurich et al. 2007, Anselmino et al. 2008, Currie et al. 2009, Baur et al. 2011, Buchs & Silverman 2011, La Vecchia 2011, Lebovitz 2011, Nandish et al. 2011, Sehra et al. 2011, Currie & Johnson 2012). The gene discussed is INS; the disease is cardiovascular disorder.