VPS35 fails to co-localize with α-synuclein-positive LB pathology within neurons located throughout the cingulate cortex of idiopathic PD/DLB cases but localizes normally to intracellular vesicles within LB-positive and LB-negative neurons from control and PD/DLB brains (Fig. 1H). This evidence concerns the gene VPS35 and Lewy body dementia.