The main text of 101 studies was carefully reviewed, and we excluded 83 papers that assessed unrelated polymorphisms, were not case-control designs, were conducted in pediatric populations, did not define obesity, or studied controls that deviated from HWE. Finally, 18 relevant studies (1 study published in English was conducted in a Chinese population) that included 2,819 cases and 3,024 controls concerning ADIPOQ-rs2241766 G/T polymorphism and obesity were eligible for the meta-analysis [17]–[22], [25]–[36]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.