This was accompanied by a reduced activation of NFκB, in β5i/LMP7-deficient cells [15] and reduced Th1 and Th17 but enhanced Treg cell differentiation of CD4+ T-cells in the lamina propria of β5i LMP7-deficient/inhibitor-treated mice with mild forms of DSS-induced colitis [15]–[17]. This evidence concerns the gene PSMB8 and colitis.