A diminished transcription of the same cytokines, IL17 and IL23 was detected also during DSS-induced colitis in β5i/LMP7-deficient, in β1i/LMP2 deficient- and in β2i/MECL-1-deficient mice, as well as in mice treated with selective inhibitors targeting the β5i/LMP7 and β5 subunits or the β5i/LMP7 subunit only [15], [16]. Here, PSMB10 is linked to colitis.