Recent studies have identified a new mechanism of TRAIL resistance observed in some glioblastoma cell lines (including TB10, U251 and U87MG) and mediated by overexpression of miR-21 and miR-30b/c, responsible for the targeting of caspase-3 and Tap63 mRNAs [27]. The gene discussed is TNFSF10; the disease is glioblastoma.