It is of interest to note the results recently reported for another drug, lanatoside C. In fact this drug, like salinomycin, acts in glioblastoma cells as a sensitizer to TRAIL-induced cell death via TRAIL-R2 upregulation; furthermore, both lanatoside C and salinomycin, on their own, induce cell death of glioblastoma cells by a caspase-independent mechanism; finally, lanatoside C, like salinomycin, causes a decrease of mitochondrial membrane potential [40]. The gene discussed is TNFRSF10B; the disease is glioblastoma.