To evaluate the effect of the contemporaneous addition of salinomycin and TRAIL in GBM cells, T98G and U251 cell lines were treated with a low concentration (i.e., 1.2 μM) of salinomycin, not suitable for inducing a significant reduction of viable cells and in the absence or in the presence of increasing concentrations of TRAIL. Here, TNFSF10 is linked to glioblastoma.