MAPK8 and metabolic dysfunction-associated steatotic liver disease: We speculated the role of MAPK pathways in ZD hepato-protective effects since the polysaccharides portion of wolfberry potently alleviated NAFLD by modulating the MAPK pathways [10] and ZD was also one of the components of wolfberry [31]., We found that chronic ethanol treatment induced the activity (phosphorylated form) of p38 MAPK and JNK but decreased ERK.