The results showed that in comparison of asthma patients with the normal control group there were 3 up-regulated genes including Integrin αV, Collagenase-1 and TIMP3 and 14 down-regulated gene including adhesive molecules: Integrinα1, Integrinα6, Integrinα8, Integrinα10, integrin β4, catenin α-like 1; extracellular matrixes: COL1ALPHA1, MCH6/ALPHAPALPHAF3, Vitronectin; protease: MMP-7, MMP-17, uPA; and protease inhibitor: TIMP-1, TIMP2 in the examined 96 genes (showed in Table S1). The gene discussed is TIMP1; the disease is asthma.